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KMID : 0613820140240030284
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Journal of Life Science
2014 Volume.24 No. 3 p.284 ~ p.289
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Inhibitory Effects of Phyllostachys bambusoides on Melanin Synthesis and Tyrosinase Activity in Cultured Human Melanoma Cells
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Huh Man-Kyu
Han Min-Ho
Park Cheol
Choi Yung-Hyun
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Abstract
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Tyrosinase is a rate-limiting enzyme that controls the production of melanin. The effect of bamboo (Phyllostachys bambusoides) on tyrosinase activity and melanin synthesis has not been studied. We analyzed the effects of leaf and inner film fractions of bamboo extracts on the inhibition of tyrosinase activity and on melanin production. At a concentration of 5 mg/ml, the extracts of bamboo down-regulated the production of melanocytes. In addition, the extracts of bamboo reduced tyrosinase activity and the melanin content in vitro. Our results suggest that bamboo extract may constrain melanin synthesis by inhibition of the activity and expression of tyrosinase.
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KEYWORD
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Bamboo, extractions, melanocyte, tyrosinase activity, melanin
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